George S. Katselis BSc, MSc, PhD

Dr. George Katselis is an Assistant Professor in the Division of the Canadian Centre for Rural and Agricultural Health (CCRAH) in the Department of Medicine, College of Medicine at the University of Saskatchewan.  George moved from his hometown Thebes in Greece to Halifax, Nova Scotia, Canada to study Instrumental Chemical Analysis/Analytical Chemistry at Dalhousie University earning a B.Sc. with Honours (supervisor: Dr. Louis Ramaley).  After a brief stay back in Greece, he returned to Canada to pursue graduate studies at the University of Saskatchewan where he earned a M.Sc. in Analytical Chemistry of Natural Products (supervisor: Dr. Branka Barl) and a Ph.D. in Pharmaceutical Sciences / Analytical Chemistry (supervisors: Dr. Dennis Gorecki & Dr. Branka Barl).  It was during his Ph.D. studies that George discovered his true passion in Mass Spectrometry.  In 2005, he moved to Los Angeles, California, USA and the City of Hope Medical Center to do his Post-Doctoral Fellowship in Mass Spectrometry (MS)-based Proteomics under the mentorship of Dr. Terry Lee, a modern era mass spectrometry pioneer.  In 2010, he returned to the University of Saskatchewan to manage the Mass Spectrometry lab and in 2012 he joined the Department of Medicine and CCRAH in his current capacity.  In 2014, he established, and currently leads, the CCRAH Mass Spectrometry Laboratory for Omics Research.

Dr. Katselis’ areas of research are in Functional and Structural Proteomics and the Biomedical Aspects of Human Health and he employs Mass Spectrometry-based techniques for: Clinical Proteomics, Metabolomics, and Lipidomics; Biomarker Analysis (Discovery and Validation); Structural Characterization of Proteins (e.g. Protein-Protein Interactions, Post-translational Modifications of Proteins); Environmental, Agricultural, Rural and Occupational Health Applications; Pharmaceutical Analysis; Analytical Instrumentation Chemistry.

• Ph.D., University of Saskatchewan, Pharmaceutical Sciences / Analytical Chemistry 
• M.Sc., University of Saskatchewan, Analytical Chemistry
• B.Sc. (Honours), Dalhousie University, Analytical Chemistry

• Donkuru M, Michel D, Awad H, Katselis G, El-Aneed A. (2016). Hydrophilic interaction liquid chromatography-tandem mass spectrometry quantitative method for the cellular analysis of varying structures of gemini surfactants designed as nanomaterial drug carriers. Journal of Chromatography A. 
• Vidhyasagar V, He Y, Guo M, Ding H, Talwar T, Nguyen V, Nwosu J, Katselis G, Wu Y. (2016). C-termini are essential and distinct for nucleic acid binding of human NABP1 and NABP2. Biochimica et Biophysica Acta (BBA) - General Subjects. 1860(2): 371-383.
• Willems J, Khamis M, Saeid WM, Purves R, Katselis G, Low N, El-Aneed A. (2016). Analysis of a series of chlorogenic acid isomersusing differential ion mobility and tandem mass spectrometry. Analytical Chimica Acta (Submitted – Under Review).
• Katselis G, Atila M, Chumala P, Luo Y. (2016). N-Succinylationof L-lysyl-phosphatidylglycerol in Bacillus subtilis. Journal of the American Society for Mass Spectrometry (Submitted – Under Review).
• Zhang L1, Katselis GS1, Moore RE, Lekpor K, Goto RM, Hunt HD, Lee TD, Miller MM. 1Equal Contribution. (2012). MHC class I target recognition, immunophenotypes and proteomic profiles of natural killer cells within the spleens of day-14 chick embryos. Developmental and Comparative Immunology. 37(3-4): 446-456.
• Watanabe J, Charles-Schoeman C, Miao Y, Elashoff D, Lee YY, Katselis G, Lee TD, Reddy ST. (2012). Proteomic profiling following immunoaffinity capture of high-density lipoprotein: association of acutephase proteins and complement factors with proinflammatory high-density lipoprotein in rheumatoid arthritis. Arthritis and Rheumatism. 64(6): 1828-1837.
• Charles-Schoeman C, Miao Y, Watanabe J, Lee YY, Katselis G, Lee TD, Reddy ST. (2011). Proteomic profiling following immunoaffinity capture of HDL identifies association of acute phase proteins and complement factors with pro-inflammatory HDL in rheumatoid arthritis. Arthritis and Rheumatism. 63(S10): 1918.
• Zhang L1, Katselis GS1, Moore RE, Lekpor K, Goto RM, Lee TD, Miller MM. 1 Equal Contribution. (2011). Proteomic analysis of surface and endosomal membrane proteins from the avian LMH epithelial cell line. Journal of Proteome Research. 10(9): 3973-3982.
• Rao NA, Saraswathy S, Wu GS, Katselis GS, Wawrousek EF, Bhat S. (2008). Elevated retina-specific expression of the small heat shock protein, A-crystallin, is associated with photoreceptor protection in experimental uveitis. Investigative Ophthalmology & Visual Science. 49(3): 1161-1171.
• Katselis GS, Estrada A, Gorecki DK, Barl B. (2007). Adjuvant activities of saponins from the root of Polygala senega L. Canadian Journal of Physiology and Pharmacology. 85(11): 1184-1194.
• Estrada A, Katselis GS, Laarveld B, Barl B. (2000). Isolation and evaluation of immunological adjuvant activities of saponins from Polygala senega L. Comparative Immunology, Microbiology & Infectious Diseases. 23(1): 27-43.

Intellectual Property – Patents:

• Polygala senega Compositions and Methods of Use. United States. 6,241,995. 1998/08/06. Patent Status: Completed. Date Issued: 2001-06-05